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5-Lipoxygenase (5-LOX)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	FLAP (3) Lipoxygenase (16) Apoptosis (2) Autophagy (1) Caspase (1) COX (4) Epoxide Hydrolase (1) Ferroptosis (1) GABA Receptor (1) Leukotriene Receptor (1) Opioid Receptor (1) PGE synthase (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Inflammation/Immunology (15) Metabolic Disease (1) Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Lipoxygenase LOX-1 FLAP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0198

Nordihydroguaiaretic acid 4 Publications Verification NDGA	Lipoxygenase Autophagy Ferroptosis	Neurological Disease Cancer
Nordihydroguaiaretic acid is a *5-lipoxygenase* (5LOX) (IC₅₀=8 μM) and tyrosine kinase inhibitor.

HY-138939

5-LOX-IN-2	Lipoxygenase	Cancer
5-LOX-IN-2, an inhibitor of 5-lipoxygenase (5-LOX) with an IC₅₀ of 0.33 μM, inhibits 5-LOX in a dose-dependent manner . 5-LOX-IN-2, reduces the cell viability of renal cancer cells and induces apoptosis, can be used for cancer research .

HY-155407

ALR-6	FLAP	Inflammation/Immunology
ALR-6 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-6 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM and has no significant effect on direct inhibition of 5-LOX .

HY-155409

ALR-38	Lipoxygenase	Inflammation/Immunology
ALR-38 is a 5-lipoxygenase (5-LOX) inhibitor (IC₅₀: 1.1 μM) with anti-inflammatory activity. ALR-38 effectively reduces ROS levels in neutrophils .

HY-155408

ALR-27	FLAP	Inflammation/Immunology
ALR-27 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-27 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM, with no significant direct inhibition of 5-LOX. ALR-27 not only reduces prostaglandin and leukotriene (LT) production in neutrophils but also increases the production of specialized prolytic mediators in specific human macrophage phenotypes .

HY-148134

5-LOX-IN-1	Lipoxygenase	Inflammation/Immunology
5-LOX-IN-1 (compound 2b) is an inhibitor of human 5-Lipoxygenase *(5-LOX)* with an IC₅₀ value of 2.3 μM. 5-LOX-IN-1 can be used for the research of inflammation .

HY-105024

FPL 62064	Lipoxygenase COX	Inflammation/Immunology
FPL 62064 is a potent **5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC₅₀** values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity .

HY-W009248

Phenethyl ferulate	COX Lipoxygenase	Inflammation/Immunology
Phenethyl ferulate is a major constituent ofQianghuo, shows inhibitory activity against cyclooxygenase (COX) and *5-lipoxygenase* (5-LOX) with IC₅₀ values of 4.35 μM and 5.75 μM, respectively .

HY-117048

PF-4191834 PF-04191834	Lipoxygenase	Inflammation/Immunology
PF-4191834 (PF-04191834) is an orally active, noniron chelating, and non-redox inhibitor of the **5-Lipoxygenase (5-LOX) (IC₅₀*=229 nM), displays ~300-fold selectivity for 5-LOX* over 12-LOX and 15-LOX, shows no activity toward the cyclooxygenase enzymes, and is effective in inflammation and pain .

HY-A0060

Malotilate NKK 105	Lipoxygenase	Cancer
Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the **5-lipoxygenase (5-LOX) (IC₅₀**=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes .

HY-W028263

6-Hydroxyflavanone	COX Opioid Receptor GABA Receptor Lipoxygenase	Metabolic Disease Inflammation/Immunology
6-Hydroxyflavanone is a compound that can be isolated from the Muntingia calabura leaves. 6-Hydroxyflavanone targets cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), and opioid and GABA-A receptors that has anti-inflammatory and anti-neuropathic pain potential. 6-Hydroxyflavanone can be used for the research of diabetes .

HY-N0551

Wedelolactone Maximum Cited Publications 14 Publications Verification	Caspase Lipoxygenase Apoptosis	Inflammation/Immunology Cancer
Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits *5-lipoxygenase* (5-Lox) with an IC₅₀ of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .

HY-111140

YS121	PGE synthase Lipoxygenase	Inflammation/Immunology
YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1; IC₅₀=3.4 μM) and 5-lipoxygenase (5-LOX; *IC₅₀*=6.5 μM). YS121 dose- dependently reduces PGE2 production with EC₅₀=12 μM in IL-1β-stimulated A549 cells .

HY-N2056

11-Keto-beta-boswellic acid 11-Keto-β-boswellic acid
11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit **5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB)** activation and tumor necrosis factor alpha generation production .

HY-125975

1-Naphthyl 3,5-dinitrobenzoate	Lipoxygenase	Inflammation/Immunology
1-Naphthyl 3,5-dinitrobenzoate is a potent *5-lipoxygenase* inhibitor with IC₅₀ values of 1.04 µM and 3.6 µM for 5-LOX and mPGES-1, respectively. 1-Naphthyl 3,5-dinitrobenzoate has strong inhibition activity in the human whole blood (HWB) assay with an IC₅₀ value of 8.6 μM. 1-Naphthyl 3,5-dinitrobenzoate can be used in research of inflammation .

HY-153279

5-LOX-IN-3	Lipoxygenase	Neurological Disease Inflammation/Immunology Cancer
5-LOX-IN-3 (Compound 14) is a *5-Lipoxygenase* inhibitor (IC₅₀: <1 μM). 5-LOX-IN-3 can be used for research of inflammatory diseases, cancer, stroke and Alzheimer's disease .

HY-U00308

5-LOX-IN-4

Lipoxygenase Cardiovascular Disease Inflammation/Immunology

5-LOX-IN-4 is a 5-Lipoxygenase inhibitor extracted from patent EP 331232 A2, table 4, compound example 4.10.

5-LOX-IN-4	Lipoxygenase	Cardiovascular Disease Inflammation/Immunology
5-LOX-IN-4 is a *5-Lipoxygenase* inhibitor extracted from patent EP 331232 A2, table 4, compound example 4.10.

HY-B1452

Licofelone 1 Publications Verification ML-3000
Licofelone (ML-3000) is a dual **COX/5-lipoxygenase (5-LOX) inhibitor (IC₅₀=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis**, and decreases the production of proinflammatory leukotrienes and prostaglandins .

HY-120502

5-LOX-IN-6	Lipoxygenase Leukotriene Receptor	Inflammation/Immunology
5-LOX-IN-6 (compound 11a) is a direct and reversible inhibitor of **5-lipoxygenase (5-LO)*. 5-LOX-IN-6 inhibits 5-LO activity in human neutrophils and recombinant human 5-LO with IC₅₀* values of 0.23 and 0.086 µM, respectively. 5-LOX-IN-6 prevents leukotriene biosynthesis. 5-LOX-IN-6 can be used for inflammatory and allergic disorders research .

HY-B1452S1

Licofelone-d6 ML-3000-d₆	Apoptosis Lipoxygenase COX
Licofelone-d₆ is the deuterium labeled Licofelone[1]. Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins[2][3][4].

HY-128171

Diflapolin 1 Publications Verification	FLAP Epoxide Hydrolase	Inflammation/Immunology
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC₅₀s of 30 and 170 nM, respectively, and suppressed the activity of isolated sEH (IC₅₀=20 nM) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0198

Nordihydroguaiaretic acid 4 Publications Verification NDGA	Structural Classification Neurological Disease Classification of Application Fields Anti-aging Source classification Lignans Plants other families Phenols Polyphenols Phenylpropanoids Disease Research Fields Cancer	Lipoxygenase Autophagy Ferroptosis
Nordihydroguaiaretic acid is a *5-lipoxygenase* (5LOX) (IC₅₀=8 μM) and tyrosine kinase inhibitor.

HY-W009248

Phenethyl ferulate	Monophenols Classification of Application Fields Isodon excisoides (Sun ex C. H. Hu) H. Hara Source classification Phenols Plants Umbelliferae Disease Research Fields Inflammation/Immunology	COX Lipoxygenase
Phenethyl ferulate is a major constituent ofQianghuo, shows inhibitory activity against cyclooxygenase (COX) and *5-lipoxygenase* (5-LOX) with IC₅₀ values of 4.35 μM and 5.75 μM, respectively .

HY-N0551

Wedelolactone 10+ Cited Publications	Structural Classification Classification of Application Fields Alysicarpus ovalifolius (Schumacher) J. Leonard Phenols Polyphenols Plants Compositae Inflammation/Immunology Disease Research Fields	Caspase Lipoxygenase Apoptosis
Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits *5-lipoxygenase* (5-Lox) with an IC₅₀ of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .

HY-W028263

6-Hydroxyflavanone	Structural Classification Flavonoids Flavonones Source classification Muntingia calabura L. Plants Muntingiaceae	COX Opioid Receptor GABA Receptor Lipoxygenase
6-Hydroxyflavanone is a compound that can be isolated from the Muntingia calabura leaves. 6-Hydroxyflavanone targets cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), and opioid and GABA-A receptors that has anti-inflammatory and anti-neuropathic pain potential. 6-Hydroxyflavanone can be used for the research of diabetes .

Cat. No.	Product Name	Chemical Structure

HY-B1452S1

Licofelone-d6
Licofelone-d₆ is the deuterium labeled Licofelone[1]. Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins[2][3][4].

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5-Lipoxygenase (5-LOX)

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Antibodies

Natural
Products